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While the majority of the oogonia continue to divide weight loss pills jackson tn order alli 60 mg online, some enter into the prophase of the first meiotic division and are called primary oocytes. These are surrounded by flat cells and are called primordial follicles and are present in the cortex of the ovary. At birth, there is no more mitotic division and all the oogonia are replaced by primary oocytes which have finished the prophase of the first meiotic division and remain in resting phase (dictyotene stage) between prophase and metaphase. The primary oocytes do not finish the first meiotic division until puberty is reached. Out of these, some 400 are likely to ovulate during the entire reproductive period. Maturation of the oocytes: the essence of maturation is reduction of the number of chromosomes to half. The two are of unequal size, the secondary oocyte contains haploid number of chromosomes (23, X), but nearly all the cytoplasm and the small polar body also contains half of the chromosomes (23, X) but with scanty cytoplasm. In the absence of fertilization, the secondary oocyte does not complete the second meiotic division and degenerates as such. Chromosome nomenclature: the number designates the total number of chromosomes (in numerals) followed by the sex chromosome constitution after the comma. Structure of a mature ovum: A fully mature ovum is the largest cell in the body and is about 130 microns in diameter. It consists of cytoplasm and a nucleus with its nucleolus which is eccentric in position and contains 23 chromosomes (23, X). The zona pellucida is penetrated by tiny channels which are thought to be important for the transport of the materials from the granulosa cells to the oocyte. In between the vitelline membrane and the zona pellucida, there is a narrow space called perivitelline space which accommodates the polar bodies. The human oocyte, after its escape from the follicle, retains a covering of granulosa cells known as the corona radiata derived from the cumulus oophorus. Shortly before puberty, the primordial germ cells develop into spermatogonia and remain in the wall of seminiferous tubules. The Chapter 2 Fundamentals of Reproduction 21 spermatogonia, in turn, differentiate into primary spermatocytes which remain in the stage of prophase of the first meiotic division for a long time (about 16 days). Then immediately follows the second meiotic division (homotypical) with the formation of four spermatids, each containing haploid number of chromosomes, two with 23, X and two with 23, Y. Immediately after their formation, extensive morphological differentiation of the spermatids occurs without further cell division to convert them into spermatozoa. In man, the time required for a spermatogonium to develop into a mature spermatozoon is about 61 days. Sperm capacitation and acrosome reaction: Capacitation is the physiochemical change in the sperm by which it becomes hypermotile and is able to bind and fertilize a secondary oocyte.

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Therefore human placenta is a discoid weight loss pills top 5 alli 60 mg purchase visa, deciduate, labyrinthine and hemochorial type (p. The outer surface consists of a layer of connective tissue and is apposed to the similar tissue on the inner aspect of the chorion from which it can be peeled off. The amnion can also be peeled off from the fetal surface of the placenta except at the insertion of the umbilical cord. Functions: (1) Contribute to the formation of liquor amnii; (2) Intact membranes prevent ascending uterine infection; (3) Facilitate dilatation of the cervix during labor; (4) Has got enzymatic activities for steroid hormonal metabolism; (5) Rich source of glycerophospholipids containing arachidonic acid - precursor of prostaglandin E2 and F2. Fluid accumulates slowly at first, but ultimately the fluid-filled cavity becomes large enough to obliterate the chorionic cavity; the amnion and the chorion come in loose contact by their mesenchymal layers. Production Transudation Removal of maternal serum across the placental Fetus swallows membranes every day. Intramembranous absorption Secretion Transudation Fetal urine Fetal lung of water and solutes (200­500 mL/day) from the amniotic compartment to fetal circulation through the fetal surface of the placenta. Chapter 3 the Placenta and Fetal Membranes 43 Initially, the cavity is located on the dorsal surface of the embryonic disk. Thus, the liquor amnii surrounds the fetus everywhere except at its attachment with the body stalk. The amnion is firmly attached to the umbilical cord up to its point of insertion to the placenta, but everywhere it can be separated from the underlying chorion. The presence of lanugo and epithelial scales in the meconium shows that the fluid is swallowed by the fetus and some of it passes from the gut into the fetal plasma (vide scheme). It measures about 50 mL at 12 weeks, 400 mL at 20 weeks and reaches its peak of 1 liter at 36­38 weeks. As the pregnancy continues post term, further reduction occurs to the extent of about 200 mL at 43 weeks. Color: In early pregnancy it is colorless, but near term it becomes pale straw colored due to the presence of exfoliated lanugo and epidermal cells from the fetal skin. Abnormal color: Deviation of the normal color of the liquor has got clinical significance. Meconium stained (green) is suggestive of fetal distress in presentations other than the breech or transverse. Depending upon the degree and duration of the distress, it may be thin or thick or pea soup (thick with flakes). But in late pregnancy, the composition is very much altered mainly due to contamination of fetal urinary metabolites. As pregnancy advances, there may be slight fall in the sodium and chloride concentration probably due to dilution by hypotonic fetal urine, whereas the potassium concentration remains unaltered. During pregnancy: (1) It acts as a shock absorber, protecting the fetus from possible extraneous injury; (2) Maintains an even temperature; (3) the fluid distends the amniotic sac and thereby allows for growth and free movement of the fetus and prevents adhesion between the fetal parts and amniotic sac; (4) Its nutritive value is negligible because of small amount of protein and salt content; however, water supply to the fetus is quite adequate. During labor: (1) the amnion and chorion are combined to form a hydrostatic wedge which helps in dilatation of the cervix; (2) During uterine contraction, it prevents marked interference with the placental circulation so long as the. Maternal abdomen is divided into quadrants taking the umbilicus, symphysis pubis and the fundus as the reference points.

Specifications/Details

Pelvic examination · Exclude obvious pelvic pathology (adnexal masses weight loss pills metabolife purchase 60 mg alli mastercard, uterine fibroids, endometriosis (painful, fixed uterus), vaginismus). Laparoscopy and dye test · Day-case procedure that can be combined with a hysteroscopy to assess the uterine cavity if necessary. Hysterosalpingo-contrast-sonograph (HyCoSy) · Ultrasound with galactose-containing contrast medium. Couples should be informed of their options and given relevant evidence-based advice so they can make an informed choice. Avoid ovulation induction kits/basal temperature measurements (no evidence of success, and stressful). Correction of the specific problem such as hyperprolactinaemia or excessive weight may be enough. Couples should be offered counselling before and after treatment, along with information regarding patient support groups. Investigation should start in primary care after 1yr, or earlier if history of genital surgery, cancer treatment, or previous subfertility. Normal male fertility is dependent on normal spermatogenesis, erectile function, and ejaculation. Success is dependent on many factors including: · Duration of subfertility: d success with i duration. Higher fertilization rates are obtained if the selected sperm exhibit some motility, but otherwise there are no strict selection criteria. Intrauterine insemination · Couples who may benefit include those with: · mild male factor subfertility · unexplained subfertility · coital difficulties · same sex couple. X There is no consensus on the role of simultaneous ovarian stimulation, but this should be considered in endometriosis and unexplained infertility when outcome is less favourable. Egg donation · May offer a chance of pregnancy for women previously considered to be irreversibly sterile. Donor insemination · Indicated in men: · with azoospermia and failed surgical sperm recovery · at high risk of transmitting genetic disorders. Sexual health necessitates the possibility of having pleasurable and safe sexual experiences, free of coercion, discrimination, and violence. Up to 50% of men will have some degree of erectile dysfunction, which rises to 67% by 70. Normal sexual function Masters and Johnson proposed four components of the sexual response: arousal/excitement, plateau, orgasm, and resolution (based on biological, predominantly male, responses). More recently, intimacy-based models include features of satisfaction, pleasure, and relationship context. Diagnosis See the woman as she chooses to present herself, with or without a partner, and explore `why now Presentation may be overt or covert-it is often useful to give the patient time to explore this and always think of the possibility of somatization of problems. Try to understand the relationship between the physical findings, such as prolapse, and the psychological reaction to them.

Syndromes

  • Menstruation
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  • On day 2, urinate into the container when you get up in the morning.
  • A family history of breat holding spells (parents may have had similar spells when they were kids)
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  • Stress incontinence -- occurs during certain activities like coughing, sneezing, laughing, or exercise.
  • Coughing

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Karlen, 44 years: Contractions (Braxton-Hicks): Uterine contraction in pregnancy has been named after BraxtonHicks who first described its entity during pregnancy. Significant number of patients are rushed to the referral hospital after repeated bouts of hemorrhage often with history of vaginal examination. The drip rate is gradually increased until effective contractions are set up (see Chapter 35).

Owen, 62 years: When pathogens (viruses) replicate inside the cells and are inaccessible to antibodies, are destroyed by T cells. The fibres of the olfactory tract pass through the lateral olfactory stria to terminate in the anterior perforated substance and in some neighbouring areas that collectively constitute the primary olfactory cortex. Where this is not possible, such women with an increased risk of placenta accreta, should be managed as if they have placenta accreta until proved otherwise.

Zakosh, 42 years: The device is expected to be expelled spontaneously with the delivery of the afterbirths. Endocrinology in relation to reproduction includes the knowledge of: Hormones essential for the maturation of the Graafian follicles, ovulation and maintenance of corpus luteum after fertilization. Supplementary intramuscular vitamin B12 100 µg daily or on alternate days may be added when response to folic acid alone is not adequate.

Hjalte, 32 years: Cesarean section is the preferred method of delivery if version fails or is contraindicated. Deficiency of vitamin B6, vitamin B1 and proteins may be the effects rather than the cause. Fetal well-being is assessed by clinical examination and also with cardiotocograph and ultrasonography for liqor volume and fetal weight.

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