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Heat energy in the form of radiation can cross empty space or travel through the atmosphere virtually without loss gastritis diet øàðëîòêà lansoprazole 30 mg buy visa. If it falls on a body capable of absorbing it, then it appears as heat, although a proportion may be reflected or transmitted. Use of microwave radiation Use of microwave radiation in the wavelength range from 10 mm to 1 m has been found to be an efficient heating and drying method. Generation and action of microwaves Microwaves are produced by an electronic device known as a magnetron. Microwave energy can be reflected down a rectangular duct (termed a waveguide) or simply beamed through a transparent polypropylene window into the drying chamber. The penetration of microwaves into the wet product is so good that heat is generated uniformly within the solid. The large molecules of the solids do not resonate as well as, say, water molecules, so further heating may be avoided once the water is removed. Clearly, the absorption of the microwave energy is far greater for small polar molecules than for larger and less polar molecules. That, in itself, is not essential for the use of microwaves but the air flow through the chamber facilitates the continuous removal of evaporated solvent. The radiation passes through the polypropylene window into the drying chamber, where it is absorbed by the liquid in the wet granules contained on a tray. When drying is nearly complete, the radiation field intensity within the chamber will rise because the dry solids do not absorb as readily as water. This rise is detected, and the magnetrons are progressively turned down automatically to give an accurate control of the final moisture content and minimize the danger of overheating. This is ensured by fail-safe devices preventing generation of microwaves until the drying chamber is sealed. Drying of solutions and suspensions the objective of the dryers used for drying of solutions and suspensions is to generate a large surface area in the liquid for heat and mass transfer and to provide an effective means of collecting the dry solid. The most useful type disperses the liquid as a spray of small droplets  the spray-dryer. Spray-drying Spray-drying is a technique that converts a liquid into a dry powder and involves rapidly spraying the liquid or slurry into a hot drying medium. This method of drying is used widely in various industries to produce dry particles with desired properties. Pharmaceutically, spray-drying can be useful for engineering particles for characteristics such as size, morphology, water content and bulk density. The spray-dryer provides a large surface area for heat and mass transfer by atomizing the liquid feed into small droplets. These are sprayed into a stream of circulating hot air such that each liquid droplet dries and solidifies to an individual particle.
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The two differ only very slightly in practice and only because water vapour does not behave exactly like an ideal gas gastritis medicina natural lansoprazole 30 mg purchase free shipping. These relationships show that the relative humidity of air is dependent not only on the amount of moisture in the air but also on its temperature. This is because the amount of water required to saturate air is itself dependent on temperature. As mentioned before, in ambient air, water is in solution in the air gases, and in this case its solubility increases with increasing temperature. If the temperature of the air is raised whilst its moisture content remains constant, the air will theoretically be capable of taking up more moisture and therefore its relative humidity falls. It is important to understand the difference between moisture content and relative humidity of air. This is important in many contexts (powder properties, granulation, drying, compaction, storage conditions) but these terms are often confused. An additional complication to be taken into account is that during a drying process both the temperature and the moisture content of the drying air (and therefore its relative humidity) could change significantly. Part of the moisture present in a wet solid may be adsorbed on surfaces of the solid or may be absorbed within its structure to such an extent that it is prevented from developing its full vapour pressure and therefore from being easily removed by evaporation. Such moisture is described as bound water and is more difficult to remove than unbound water. Adsorbed water is attached to the surface of the solid as individual water molecules, which may form a monolayer (or bilayer) on the solid surface. Absorbed bound water exists as a liquid but is trapped in capillaries within the solid by surface tension. Moisture content of air An added complication to the drying process is that the drying air also contains moisture. Many pharmaceutical plants have air-conditioning systems to reduce the humidity of the incoming process air, but removing water from air is a very expensive process and therefore not all the water will be removed. The moisture content of air is expressed as kilograms of water per kilogram of bone-dry (water-free) air. The moisture content of air is altered not only by changes in its temperature alone but also by changes in the amount of moisture taken up by the air. The moisture content of air should be carefully distinguished from the relative humidity. Relative humidity of air Ambient air is a simple solution of water in a mixture of gases and as such follows the rules of most solutions  such as increased water solubility with increasing temperature, a maximum solubility at a particular temperature (saturation) and precipitation of the solute on cooling (condensation, rain! Lower relative humidities can be quantified in terms of percentage relative humidity, which is given by vapour pressure of water vapour in air ×100 0 a vapour pressure of water vapour in the air saturated at the same temperature (29. If evaporation is high and vapour removal inefficient, the drying efficiency will rapidly fall. If the cooling is excessive, the temperature of the air may fall to a value known as the dew point.
In addition chronic gastritis low stomach acid lansoprazole 15 mg low price, the relative expense of organic solvents as a raw material has to be considered. For a given process, the amount of organic solvent retained in the film coat must be investigated, especially since there is increasing regulatory pressure to quantify and limit the residue levels. Such disadvantages have provided the momentum for the current utilization of aqueous coating formulations as the preferred option. However, as a result of improved efficiency and decreased costs associated with solvent recovery, there has been an upsurge in interest in solvent coating but almost exclusively in modified-release coating applications. When designing film-coating formulations, formulators often find it useful to use specialized assessment techniques that allow the properties of the individual ingredients being considered (including their potential beneficial interactions), of the coating formulations, and of the final coated product to be evaluated. A review of many of these useful assessment techniques has been provided by Porter & Felton (2010). Defects and imperfections in the coat can occur if the formulation of the coat and the core, or the coating process, is not adequately designed and controlled. The defects that are commonly attributed to film coating are usually: Aqueous polymer dispersions Essentially, all polymers used in modified-release film-coating applications are, in order to achieve their intended functionality, generally insoluble in water. The growing demand for aqueous formulations in modern film-coating processes thus initially caused a dilemma for pharmaceutical formulators, a dilemma that has ultimately been resolved by creating aqueous polymer dispersions of many of these polymers. By far the most common defects are those in the former category, and these have been described in detail by Rowe (1992), with suggestions for their resolution. These are typically associated Ideal characteristics of film-coated products A film-coated product and its associated manufacturing process should be designed and controlled to ensure that the following characteristics are evident: 588 with an imbalance between the rate of delivery of the coating liquid and the rate of evaporation during the drying process. This imbalance results in either overwetting (where tablets or multiparticulates might become stuck together) or overdrying, when surface erosion of the tablets, as well as chipping of the tablet edges, may result. These are usually associated with some deficiency in the core (tablet or multiparticulate) or the coating. Coating formulation issues often result in a film of inadequate mechanical strength, leading to film cracking and chipping, or inadequate film adhesion, resulting in film peeling and logo bridging. Sugar coating Sugar coating has long been the traditional method for coating pharmaceutical products (usually tablets). It involves the successive application of sucrose-based coating formulations to tablet cores in suitable coating equipment. Conventional panning equipment with manual application of syrup has been extensively used, although more specialized equipment and automated methods are now making an impact on the process. Types of sugar coatings Sugar coatings are composed of ingredients that are readily soluble, or disintegrate rapidly, in water. Although it is technically feasible to apply sugar coatings to a wide range of pharmaceutical core materials, it is almost exclusively reserved for coating tablets.
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Umul, 32 years: The moisture content of air is altered not only by changes in its temperature alone but also by changes in the amount of moisture taken up by the air. Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomas.
Einar, 25 years: Other processes, such as chemical degradation and movement of the drug away from the absorption site(s), will also contribute to the gradual decrease in the drug concentration with time at the absorption site. As the vapour pressure of the solution is lower than that of pure solvent at the same temperature, water will continue to condense until equilibrium between the vapour pressures is reached.
Mortis, 33 years: Some studies have specifically reported on the effect of original particle shape on tablet strength. As the drug is taken up into the ring, the tissue needs to be digested and the drug extracted from it before it is assayed.
Diego, 51 years: Although the tendency nowadays is to develop multipledosing devices, other hard-capsule-based devices, working on similar principles are still available. A rapid systemic drug effect can thus be obtained without first-pass liver metabolism.
Kerth, 58 years: Subcutaneous injection of insulin causes few problems, but lipodystrophy may occur if injections are given repeatedly into the same area. The mucus layer, whose thickness and turnover rates can vary along the length of the gastrointestinal tract, can hinder drug diffusion.
Candela, 38 years: However, in many instances it is left to the scientists to decide the best conditions. For some drugs, such as phenytoin, whose elimination is not described by first-order kinetics, the oral administration of equal doses at fixed time intervals may not result in the attainment of steady-state plasma levels of the drug.